SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patients.
Laís Teodoro da SilvaMarina Mazzilli OrtegaBruna Tiaki TiyoIsabelle Freire Tabosa VianaTayná Evily de LimaTânia Regina Tozetto-MendozaLuanda Mara da Silva OliveiraFranciane Mouradian Emidio TeixeiraRoberto Dias Lins NetoAlexandre de AlmeidaMaria Cássia Mendes-CorreaAlberto Jose da Silva DuarteTelma Miyuki OshiroPublished in: Clinics (Sao Paulo, Brazil) (2021)
Determination of the cellular immune response to stimulation with a pool of SARS-CoV-2 peptides but not with SARS-CoV-2 proteins is able to distinguish convalescent individuals from unexposed individuals. Regarding the humoral immune response, the screening for serum IgG antibodies directed to SARS-CoV-2 proteins has been shown to be specific for the response of recovered individuals.