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Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici.

Yanjing ZhengKe MaHaining LyuYing HuangHong-Wei LiuLing LiuYongsheng CheXingzhong LiuHuixi ZouWen-Bing Yin
Published in: Organic letters (2017)
By deleting the COP9 signalosome subunit PfcsnE from Pestalotiopsis fici, seven compounds that were newly produced by the mutant could be characterized, including five new structures, pestaloficins A-E (1 and 3-6). Pestaloficin A (1) represents a new type of dimeric cyclohexanone derivative linked through an unprecedented pentacyclic spiral ring.
Keyphrases
  • small molecule
  • protein kinase
  • genome wide
  • high resolution
  • high throughput
  • wild type
  • dna methylation