Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping.
Michael E BelloySarah J EgerYann Le GuenVincent DamotteShahzad AhmadM Arfan IkramAlfredo RamirezAnthoula C TsolakiGiacomina RossiIris E JansenItziar de RojasKayenat ParveenKristel SleegersMartin IngelssonMikko HiltunenNajaf AminOle AndreassenPascual Sánchez-JuanPatrick KehoePhilippe AmouyelRebecca SimsRuth Frikke-SchmidtWiesje M van der FlierJean-Charles Lambertnull nullZihuai HeSummer S HanValerio NapolioniMichael D GreiciusPublished in: Alzheimer's research & therapy (2022)
We showed that careful consideration of APOE genotype and appropriate sample filtering were crucial to robustly interrogate the role of the APOE locus on AD risk. Our study presents a novel APOE filtering approach and provides important guidelines for research into the APOE locus, as well as for elucidating genetic interaction effects with APOE*2/3/4.