Arsenic: A Perspective on Its Effect on Pioglitazone Bioavailability.

María Cruz Del Rocío Terrones-Gurrola Patricia Ponce-PeñaJosé Manuel Salas-PachecoAbelardo Camacho-LuisAmaury de Jesús Pozos-GuillénGuillermo Nieto-DelgadoOlga Dania López-GuzmánAngel Antonio Vértiz-Hernández

Published in: International journal of environmental research and public health (2023)

The results indicate that the substitution of Fe for As modifies the enzymatic function of CYP 3A4 and CYP 2C8 isoforms, altering the metabolic process of CYP 2D6 and CYP 3A4 in patients with T2DM. Consequently, the variation in metabolism alters the bioavailability of pioglitazone and the expected final effect.

Keyphrases

drinking water
hydrogen peroxide
heavy metals
risk assessment
adipose tissue
skeletal muscle
nitric oxide
insulin resistance