Presence of heat shock protein 47-positive fibroblasts in cancer stroma is associated with increased risk of postoperative recurrence in patients with lung cancer.
Takuto MiyamuraNoriho SakamotoKaori IshidaTomoyuki KakugawaHirokazu TaniguchiYoshiko AkiyamaDaisuke OkunoAtsuko HaraTakashi KidoHiroshi IshimotoTakuro MiyazakiKeitaro MatsumotoTomoshi TsuchiyaHiroyuki YamaguchiTaiga MiyazakiYasushi ObaseYuji IshimatsuTakeshi NagayasuHiroshi MukaePublished in: Respiratory research (2020)
The present study demonstrated that the presence of a high number of HSP47-positive fibroblasts in the cancer stroma was a risk factor for recurrence of lung cancer after surgery.