Development and validation of a UPLC-MS/MS method to investigate the plasma pharmacokinetics of a K Ca 2.2/K Ca 2.3 positive allosteric modulator in mice.
Mohammad Asikur RahmanDevaraj Venkatapura ChandrashekarYoung-Woo NamBasir SyedDavid SalehiHamidreza Montazeri AliabadiMiao ZhangReza MehvarPublished in: Rapid communications in mass spectrometry : RCM (2023)
The developed assay is suitable for preclinical pharmacokinetic-pharmacodynamic studies of 2q as a potential drug candidate for ataxias.
Keyphrases
- ms ms
- small molecule
- protein kinase
- high throughput
- high fat diet induced
- simultaneous determination
- liquid chromatography tandem mass spectrometry
- cell therapy
- type diabetes
- risk assessment
- human health
- case control
- emergency department
- high resolution
- mesenchymal stem cells
- mass spectrometry
- adverse drug
- bone marrow
- electronic health record