Paradoxical interaction between cancer and long-term postsepsis disorder: impairment of de novo carcinogenesis versus favoring the growth of established tumors.
Caio Abner LeiteJose Mauricio MotaKalil Alves de LimaCarlos Wagner WanderleyLeticia Almeida NascimentoMarcela Davoli FerreiraCamila Meirelles Souza SilvaDavid Fernando ColonJuliana Yumi SakitaVinicius KannenPaula Ramos ViacavaMaria Dirlei BegnamiRoberto Cesar Pereira Lima-JuniorVladmir Claudio Cordeiro de LimaJose Carlos Alves-FilhoFernando Queiroz CunhaRonaldo Albuquerque RibeiroPublished in: Journal for immunotherapy of cancer (2021)
Our results provide evidence that postsepsis disorder has a dual effect in cancer development, inhibiting inflammation-induced early carcinogenesis in a Treg-dependent manner, while increasing the growth of previously established tumors.