Homoharringtonine promotes non-small-cell lung cancer cell death via modulating HIF-1α/ERβ/E2F1 feedforward loop.

Qi SuJiayan RenKun ChenSze Wei LeongXu HanNa LiJianlin WuYanmin Zhang

Published in: The Journal of pharmacy and pharmacology (2024)

The formation of the HIF-1α/ERβ/E2F1 feedforward loop promotes NSCLC growth and reveals a novel molecular mechanism by which HHT induces cell death in NSCLC.

Keyphrases

cell death
small cell lung cancer
advanced non small cell lung cancer
cell cycle arrest
estrogen receptor
transcription factor
endoplasmic reticulum
endothelial cells
breast cancer cells
signaling pathway
brain metastases
epidermal growth factor receptor