Functional LTCC-β 2 AR Complex Needs Caveolin-3 and Is Disrupted in Heart Failure.

Jose L Sanchez-Alonso Laura Fedele Jaël S CopierCarla LucarelliCatherine MansfieldAleksandra JudinaSteven R Houser Thomas Brand Julia Gorelik

Published in: Circulation research (2023)

ARs tune the response of LTCCs to adrenergic stimulation in healthy conditions. This coupling is lost in heart failure; restoring it could improve the adrenergic response of failing cardiomyocytes.

Keyphrases

heart failure
left ventricular
atrial fibrillation
cardiac resynchronization therapy
acute heart failure
room temperature
ionic liquid