Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS.
Esteban Arrieta-BolañosLars L J van der BurgTobias Gedde-DahlMarie RobinUrpu SalmenniemiNicolaus M KrögerIbrahim Yakoub AghaAnne HuynhCharles R CrawleyErick DeconinckClaude-Eric BulaboisEdouard ForcadeEleni TholouliJoost G K van der HemPeter van BalenJorinde Desiree HoogenboomLiesbeth C de WreedeFlorent MalardAnnalisa RuggeriKatharina FleischhauerPublished in: Blood (2024)
HLA-DP permissive mismatches can be assigned a direction according to their immunopeptidome divergence across core and non-core subsets. Non-core permissive GvH mM show significantly reduced risks of relapse (HR 0.77 [0.63-0.93]; p<0.001) without increased NRM compared to allele-matched pairs.