The effects of acute tryptophan depletion on instrumental reward learning in anorexia nervosa - an fMRI study.
Julius HennigFranziska RitschelIlka BoehmDaniel GeislerJoseph A KingVeit RoessnerMichael N SmolkaFlorian Daniel ZepfPublished in: Psychological medicine (2022)
The precise pattern of results is suggestive of a 'normalization' of reward-related neural responses during ATD in recAN compared to HC. Our results lend further evidence to the 5-HT hypothesis of AN. Decreasing central nervous 5-HT synthesis and availability during ATD and possibly also by dieting may be a means to normalize 5-HT availability and associated brain processes.