Effects of Aspergillus fumigatus Conidia on Apoptosis and Proliferation in an In Vitro Model of the Lung Microenvironment.

Hisako KushimaToshiyuki TsunodaTaichi MatsumotoYoshiaki KinoshitaKoichi IzumikawaSenji ShirasawaMasaki FujitaHiroshi Ishii

Published in: Microorganisms (2021)

AF affects both apoptosis of epithelial cells and the growth of fibroblasts. A deeper understanding of the detailed mechanisms underlying Aspergillus-mediated signaling pathway in epithelial cells and fibroblasts will help us to understand the lung microenvironment.

Keyphrases

signaling pathway
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
pi k akt
stem cells
cell death
extracellular matrix
induced apoptosis
epithelial mesenchymal transition