Characterization of Potential Target Genes of Borneol in Increasing Trastuzumab Sensitivity in HER2+ Trastuzumab-Resistant Breast Cancer: Bioinformatics and In Vitro Studies.

Intan Ayu LestariI Made Rhamandana PutraNurul FatimahNavista Sri Octa UjiantariDyaningtyas Dewi Pamungkas PutriAdam Hermawan

Published in: Asian Pacific journal of cancer prevention : APJCP (2024)

BOR improved the cytotoxic effects of TRZ on HCC1954 and HCC1954-TR cell lines, where it specifically targets AR, ESR1, and GPT genes. In addition, the BOR effect, which counteracted the resistance of HCC1954-TR cells to TRZ, was mediated by genes CYP19A1, CYP17A1, NR3C1, IL-1, and RELA. However, additional research is required to validate their role in BOR activity to circumvent the resistance of HER2+ BC to TRZ.

Keyphrases

genome wide
bioinformatics analysis
genome wide identification
epidermal growth factor receptor
induced apoptosis
genome wide analysis
cell cycle arrest
metastatic breast cancer
dna methylation
human health
case control
anti inflammatory