Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes.

Saba Rezaei-LotfiFilip VujovicMary SimonianNeil HunterRamin Hamidi Farahani

Published in: Genome biology (2021)

These findings suggest that the global transcriptional landscape not only shapes the functional cellular identity of pericytes, but also stabilizes lineage memory by silencing the competing neural program within a repressed chromatin state.

Keyphrases

gene expression
transcription factor
single cell
dna damage
quality improvement
working memory
genome wide
copy number
dna methylation
heat shock
oxidative stress
cell fate