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The DESolve® novolimus bioresorbable scaffold.

Pierluigi DemolaFrancesco MeucciMiroslava StolcovaCarlo Di MarioAlessio Mattesini
Published in: Future cardiology (2021)
A longtime aspiration of interventional cardiologists remains to improve the long-term impact of stent permanence in coronaries to restore original vessel patency and physiological endothelium response. Bioresorbable vascular scaffolds were considered revolutionary in coronary devices, but several trials were disappointing; thus, the challenge in this field remains. DESolve is a novolimus-eluting poly-L-lactide-based polymer scaffold that dissolves through a bio-reabsorption mechanism, vanishing completely in 2 years. Its ability to supply the necessary radial strength to support the vessel for the critical early months after delivery is an important feature showing a unique self-correction property, which reduces incomplete stent apposition. Overexpansion has a good, safe margin with DESolve. This review aims to provide an overview of this controversial topic.
Keyphrases
  • tissue engineering
  • ultrasound guided
  • coronary artery disease
  • coronary artery
  • nitric oxide
  • machine learning
  • deep learning
  • heart failure
  • left ventricular
  • aortic stenosis
  • neural network
  • atrial fibrillation