Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis.
David R ZiehrFei LiK Mark ParnellNathan M KrahKevin J LeahyChristelle GuillermierJack VaronRebecca M BaronBradley A MaronNancy J PhilpLida P HaririEdy Y KimMatthew L SteinhauserRachel S KnipeJared RutterWilliam M OldhamPublished in: bioRxiv : the preprint server for biology (2024)
Small molecule inhibitors of lactate transporters, including the novel MCT4 inhibitor VB253, reprogram fibroblast metabolism to prevent myofibroblast differentiation and decrease bleomycin-induced pulmonary fibrosis.