Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer.

Shruthi SriramkumarRiddhi SoodThomas D HuntingtonAhmed H GhobashiTruc T VuongTara X MetcalfeWeini WangKenneth P NephewHeather M O'Hagan

Published in: Journal of translational medicine (2022)

These findings on metabolic pathways altered by platinum-based chemotherapy have uncovered key targets that can be exploited therapeutically to block the platinum-induced enrichment of OCSCs, ultimately improving the survival of OC patients.

Keyphrases

high glucose
diabetic rats
cancer stem cells
end stage renal disease
ejection fraction
newly diagnosed
oxidative stress
chronic kidney disease
prognostic factors
drug induced
squamous cell carcinoma
locally advanced
free survival