Imaging of adeno-associated viral capsids for purposes of gene editing using CEST NMR/MRI.

Bonnie LamMark VelasquezTomoko OgiyamaKevin GodinesFan-Yun SzuA J Velasquez-MaoWissam AlGhuraibawiJingshen WangPhillip B MessersmithMoriel H Vandsburger

Published in: Magnetic resonance in medicine (2024)

AAV2 viral capsids exhibit strong capacity as an endogenous CEST contrast agent and can potentially be used for monitoring and evaluation of AAV vector-mediated gene therapy protocols.

Keyphrases

gene therapy
high resolution
magnetic resonance
sars cov
contrast enhanced
magnetic resonance imaging
computed tomography
diffusion weighted imaging
mass spectrometry