Circulating Hodgkin cells: A clinicopathologic analysis of seven patients and a review of the literature.
Tariq N Al-AdilyPublished in: International journal of laboratory hematology (2020)
Hodgkin cell leukemia is very rare and represents a terminal event in the course of the disease of any histologic subtype. It is strongly associated with poor prognostic factors of HL such as advanced clinical stage, male gender, and the presence of anemia and lymphopenia. Circulating Hodgkin cells are few in number and thus can be missed in routine blood film examination. We describe the morphologic features of leukemic Hodgkin cells in details in order to help pathologists identify them for both diagnostic and research purposes.
Keyphrases
- prognostic factors
- induced apoptosis
- cell cycle arrest
- hodgkin lymphoma
- end stage renal disease
- chronic kidney disease
- acute myeloid leukemia
- oxidative stress
- stem cells
- newly diagnosed
- signaling pathway
- cell death
- bone marrow
- ejection fraction
- single cell
- peritoneal dialysis
- mesenchymal stem cells
- clinical practice
- patient reported outcomes