Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation.
Megan MulhollandMarie A C DepuydtGabriel JakobssonIrena LjungcrantzAndrietta GrentzmannFong ToEva BengtssonElin Jaensson GyllenbäckCaitríona GrönbergSara RattikDavid LibergAlexandru SchiopuHarry BjörkbackaJohan KuiperIlze BotBram SlütterDaniel EngelbertsenPublished in: Cardiovascular research (2024)
Limiting IL1RAP-dependent cytokine signalling pathways in atherosclerotic mice reduces plaque burden and plaque inflammation, potentially by limiting plaque chemokine production.