Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity.

Anton LindbergRyosuke ArakawaTsuyoshi NogamiSangram NagMagnus SchouCharles S ElmoreLars FardeVictor W PikeChrister Halldin

Published in: EJNMMI research (2019)

Three 5-HT1B PET radioligands were identified with differing intrinsic activity that could be used in imaging high- and low-affinity states of 5-HT1B receptors using PET. From this limited study, radioligand sensitivity to endogenous 5-HT appears to depend on agonist efficacy. More extensive studies are required to substantiate this suggestion.

Keyphrases

pet ct
positron emission tomography
computed tomography
high resolution
pet imaging
fluorescence imaging
photodynamic therapy
human health
case control
capillary electrophoresis