Comparative Assessment of Diagnostic Homologous Recombination Deficiency-Associated Mutational Signatures in Ovarian Cancer.

Zsófia M Sztupinszki Miklos Diossy Judit BörcsökAurel ProszNanna CorneliusMaj K KjeldsenMansoor R MirzaZoltan Szallasi

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

When WES data are available, methods that quantify only large chromosomal alterations such as the HRD score and HRDetect that captures a wider array of HRD-induced genomic aberrations are equally efficient identifying HRD ovarian cancer cases.

Keyphrases

copy number
dna repair
dna damage
genome wide
high glucose
diabetic rats
electronic health record
high resolution
high throughput
big data
dna methylation
drug induced
machine learning
high density
data analysis