Amides and Flavonoids from the Fruit and Leaf Extracts of Melodorum siamensis.
Wuttichai JaideeRaymond J AndersenMiguel A G ChavezYan A WangBrian O PatrickStephen G PyneChatchai MuanprasatSuparerk BorwornpinyoSurat LaphookhieoPublished in: Journal of natural products (2019)
Four new chalcones (1, 10, 13, and 14), a new flavanone, (9), a new amide (8), and 19 known compounds were acquired from Melodorum siamensis. The structures were established by NMR and MS data analyses. Compounds 1 (er 1.4:1) and 2 (er 1.1:1) were scalemic and were resolved to yield (-)-1 and (+)-1 and (-)-2 and (+)-2, respectively. The absolute configurations of these compounds were determined from experimental and calculated ECD data. The structures and configurations of (-)-2 and (+)-8 were identified by single-crystal X-ray diffraction analysis. Compound 11 showed nuclear factor-κB inhibitory effects (IC50 = 9 μM) in a pancreatic β cell line (MIN-6 cells).
Keyphrases
- nuclear factor
- high resolution
- toll like receptor
- electronic health record
- induced apoptosis
- mass spectrometry
- big data
- estrogen receptor
- endoplasmic reticulum
- multiple sclerosis
- magnetic resonance
- breast cancer cells
- cell cycle arrest
- ms ms
- solid state
- data analysis
- machine learning
- electron microscopy
- signaling pathway
- cell proliferation
- inflammatory response