Uncovering the Mechanism of Curcuma in the Treatment of Ulcerative Colitis Based on Network Pharmacology, Molecular Docking Technology, and Experiment Verification.

Suxian Liu Qiaodong LiFengzhi LiuHui CaoJun LiuJingyi ShanWenchao Dan Jianye Yuan Jiang Lin

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

Curcuma relieved the colon inflammation of ulcerative colitis via inactivating TNF pathway, inflammatory bowel disease pathway, and epithelial cell signaling in Helicobacter pylori infection pathway, probably by binding to STAT3 and TNF-α.

Keyphrases

ulcerative colitis
molecular docking
helicobacter pylori infection
rheumatoid arthritis
helicobacter pylori
oxidative stress
molecular dynamics simulations
cell proliferation
replacement therapy
network analysis