C-reactive protein flare predicts response to checkpoint inhibitor treatment in melanoma.

Julian Kött Noah ZimmermannTim ZellIsabel HeidrichGlenn GeidelAlessandra RüngerDaniel J SmitMyriam MerkleNiousha ParnianInga HansenInka HoehneFinn AbeckLeopold TorsterMichael WeichenthalKlaus PantelStefan W Schneider Christoffer Gebhardt

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2024)

Early CRP kinetics could indicate a response to ICI with improved OS and RFS/PFS. CRP flare and CRP response indicating significantly improved outcomes compared to CRP non-responders.

Keyphrases

dna damage
cell cycle
cell proliferation
metabolic syndrome
adipose tissue
oxidative stress