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Fibroblast Smad7 Induction Protects the Remodeling Pressure-Overloaded Heart.

Claudio HumeresArti V ShindeIzabela Dorota TuletaSilvia C HernandezAnis HannaShuaibo HuangHarikrishnan VenugopalJennifer T AguilanSimon J ConwaySimone SidoliNikolaos G Frangogiannis
Published in: Circulation research (2024)
The antifibrotic effects of Smad7 in the pressure-overloaded heart protect from dysfunction and involve not only reduction in collagen deposition but also suppression of MMP2-mediated matrix denaturation and paracrine effects that suppress macrophage activation through inhibition of matricellular proteins.
Keyphrases
  • epithelial mesenchymal transition
  • transforming growth factor
  • heart failure
  • atrial fibrillation
  • wound healing
  • oxidative stress
  • signaling pathway
  • cell migration
  • tissue engineering