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Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment.

K SchuryA M KoenigD IseleA L HulbertS KrauseM UmlauftS KolassaU ZiegenhainA KarabatsiakisF ReisterH GuendelJ M FegertIris-Tatjana Kolassa
Published in: BMC psychiatry (2017)
Results suggest that the steroid milieu of the mother, at least on the level of DHEA, is altered after CM, possibly leading to non-genomic transgenerational effects on the developing fetus in utero. Indeed, we observed on an explorative level first hints that the endocrine milieu for the developing child might be altered in CM mothers. These results need extension and replication in future studies. The measurement of hair steroids in mothers and their newborns is promising, but more research is needed to better understand the effects of a maternal history of CM on the developing fetus.
Keyphrases
  • birth weight
  • pregnancy outcomes
  • pregnant women
  • mental health
  • gestational age
  • current status
  • gene expression
  • copy number
  • body mass index
  • dna methylation
  • cord blood
  • weight gain
  • genome wide