MODELLING CHANGES IN THE PHARMACOKINETICS OF TACROLIMUS DURING PREGNANCY AFTER KIDNEY TRANSPLANTATION: A RETROSPECTIVE COHORT STUDY.

Maaike R SchagenA N UluM I FranckeJ van de WeteringM C van BurenS SchoenmakersM MaticR H N van SchaikD A HesselinkB C M de Winter

Published in: British journal of clinical pharmacology (2023)

Tacrolimus clearance increases during pregnancy, resulting in decreased exposure to tacrolimus, which is explained by gestational age and haematocrit. To maintain pre-pregnancy target whole-blood tacrolimus pre-dose concentrations during pregnancy, increasing the dose is required.

Keyphrases

gestational age
preterm birth
birth weight
pregnancy outcomes