Placental DNA methylation changes associated with maternal prepregnancy BMI and gestational weight gain.

Deepika ShresthaMarion OuidirTsegaselassie WorkalemahuXuehuo ZengFasil Tekola-Ayele

Published in: International journal of obesity (2005) (2020)

We identified placental DNA methylation changes at novel loci associated with prepregnancy BMI and GWG. The overlap between CpGs associated with obesity traits in placenta and other tissues in children and adults suggests that epigenetic mechanisms in placenta may give insights to early origins of obesity.

Keyphrases

weight gain
dna methylation
genome wide
birth weight
body mass index
gene expression
weight loss
copy number
young adults
metabolic syndrome
pregnancy outcomes
adipose tissue