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Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations.

Simion I ChioseaLester D R ThompsonIlan WeinrebJulie E BaumanAlyssa M MahaffeyCaitlyn MillerMatthew J FerrisWilliam E Gooding
Published in: Cancer (2016)
The genetic profile of SDC varies with the absence or presence of pre-existing PA and its cytogenetic signature. Most de novo SDCs harbor combined HRAS/PIK3CA mutations and no ERBB2 amplification. Cancer 2016;122:3136-44. © 2016 American Cancer Society.
Keyphrases
  • papillary thyroid
  • squamous cell
  • copy number
  • squamous cell carcinoma
  • lymph node metastasis
  • tyrosine kinase
  • childhood cancer
  • peripheral blood
  • young adults
  • nucleic acid
  • label free