Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations.
Simion I ChioseaLester D R ThompsonIlan WeinrebJulie E BaumanAlyssa M MahaffeyCaitlyn MillerMatthew J FerrisWilliam E GoodingPublished in: Cancer (2016)
The genetic profile of SDC varies with the absence or presence of pre-existing PA and its cytogenetic signature. Most de novo SDCs harbor combined HRAS/PIK3CA mutations and no ERBB2 amplification. Cancer 2016;122:3136-44. © 2016 American Cancer Society.