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Integrated DNA and RNA sequencing reveals targetable alterations in metastatic pediatric papillary thyroid carcinoma.

Samara L PotterJacquelyn ReutherRaghu ChandramohanIlavarasi GandhiFaith HollingsworthHadi SayeedHoratiu VoicuNipun KakkarKoel Sen BaksiStephen F SarabiaMonica E LopezDaniel C CheliusIoanna D AthanassakiPriya MahajanRajkumar VenkatramaniNorma M QuintanillaDolores H Lopez-TerradaAngshumoy RoyD Williams Parsons
Published in: Pediatric blood & cancer (2020)
Targetable alterations were identified in 75% of pediatric PTC cases with both DNA and RNA evaluated. Inclusion of RNA sequencing for detection of fusion genes is critical for evaluation of these tumors. Patients with fusion-positive tumors were more likely to have features of high-risk disease.
Keyphrases
  • single cell
  • circulating tumor
  • cell free
  • single molecule
  • nucleic acid
  • squamous cell carcinoma
  • small cell lung cancer
  • lymph node
  • lymph node metastasis
  • genome wide
  • gene expression
  • real time pcr