Integrated DNA and RNA sequencing reveals targetable alterations in metastatic pediatric papillary thyroid carcinoma.
Samara L PotterJacquelyn ReutherRaghu ChandramohanIlavarasi GandhiFaith HollingsworthHadi SayeedHoratiu VoicuNipun KakkarKoel Sen BaksiStephen F SarabiaMonica E LopezDaniel C CheliusIoanna D AthanassakiPriya MahajanRajkumar VenkatramaniNorma M QuintanillaDolores H Lopez-TerradaAngshumoy RoyD Williams ParsonsPublished in: Pediatric blood & cancer (2020)
Targetable alterations were identified in 75% of pediatric PTC cases with both DNA and RNA evaluated. Inclusion of RNA sequencing for detection of fusion genes is critical for evaluation of these tumors. Patients with fusion-positive tumors were more likely to have features of high-risk disease.