Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability.
Hye Min JangMyung Hwan JungJae Sang LeeJun Sig LeeIn-Cheol LimHyunsik ImSang Wook KimSung-A KangWon-Je ChoJun Kue ParkPublished in: Nanomaterials (Basel, Switzerland) (2022)
We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope 64 Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T 2 MRI nanoprobe due to their good r 2 / r 1 ratio. Furthermore, we demonstrate that the 64 Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.