Trastuzumab does not bind rat or mouse ErbB2/neu: implications for selection of non-clinical safety models for trastuzumab-based therapeutics.

Gail D Lewis PhillipsJun GuoJames R KieferWilliam ProctorDaniela Bumbaca YadavNoel DybdalBen-Quan Shen

Published in: Breast cancer research and treatment (2021)

These data, in total, demonstrate that trastuzumab, and by extension T-DM1, do not bind rat or mouse neu, underscoring the importance of species selection for safety studies investigating trastuzumab or trastuzumab-based therapeutics.

Keyphrases

epidermal growth factor receptor
metastatic breast cancer
tyrosine kinase
oxidative stress
small molecule
adipose tissue
machine learning
metabolic syndrome