RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9.

Mengli ZhangJudith HyleXiaowen ChenYe XinYingcai JinJianxiang ZhangXue YangXinfeng ChenShaela WrightZhenling LiuWojciech RosikiewiczBeisi XuLiusheng HeHong LiuNana PingDepei WuFeiqiu WenChunliang LiPeng Xu

Published in: Genome biology (2024)

We identify RBM5 as a new upstream regulator of HOXA9 and reveal its essential role in controlling the survival of AML. These functional and molecular mechanisms further support RBM5 as a promising therapeutic target for myeloid leukemia treatment.

Keyphrases

acute myeloid leukemia
binding protein
long non coding rna
transcription factor
long noncoding rna
signaling pathway
dendritic cells
gene expression
genome wide
immune response
small molecule
free survival
protein protein
nucleic acid