Basal cell carcinoma (BCC) is one of the most leading skin cancers. However, risk factors of BCC, especially non-environmental features, have not been completely identified. Consequently, we conducted a Mendelian randomization (MR) analysis to explore possible causal risk factors in a cohort of millions of Europeans. We attained genetic variants of risk factors from publicly available genome-wide association studies. Eventually, the present MR study analyzed 43 risk factors, and demonstrated that telomere length [odds ratio (OR): 1.53, 95% confidence interval (CI) 1.35-1.74, p<0.0001], birth weight (OR: 1.13; 95% CI 1.01-1.26, p=0.03), and height (OR: 1.07; 95% CI 1.01-1.13, p=0.02) may casually related to an increased risk of BCC. Nonetheless, no genetic liability between BCC risk and other risk factors was noted. These findings supported prevention strategies and managements for BCC should be considered in high-risk population.