Protective effects of NAC and salubrinal on apoptosis of retinal pigment epithelial cells induced by all-trans retinoic acid.

Juan WuDongmei CuiHonghui LiJunwen Zeng

Published in: European journal of ophthalmology (2021)

In ARPE-19 cells, the levels of ROS and ERS can be increased by ATRA, contributing to apoptosis, which can be effectively inhibited by NAC and salubrinal. Thus, ATRA may play an important role in the prevention, diagnosis and treatment of age-related macular degeneration.

Keyphrases

cell cycle arrest
cell death
age related macular degeneration
endoplasmic reticulum stress
induced apoptosis
transcription factor
pi k akt
oxidative stress
signaling pathway
dna damage
genome wide analysis