Alkaline phosphatase in pulmonary inflammation-a translational study in ventilated critically ill patients and rats.
Jenny JuschtenSarah A IngelseLieuwe D J BosArmand R J GirbesNicole P JuffermansTom van der PollMarcus J SchultzPieter Roel Tuinmannull nullPublished in: Intensive care medicine experimental (2020)
In ventilated critically ill patients, pulmonary AP activity correlates well with markers of pulmonary inflammation, such as IL-6 and IL-8. In animals with lung injury, pulmonary AP activity is elevated. Administration of recombinant AP does not alter pulmonary inflammation and endothelial or epithelial dysfunction in the acute phase of a murine lung injury model.