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Accelerated Discovery in Photocatalysis by a Combined Screening Approach Involving MS Tags.

Michael TedersSabrina BernardKarin GottschalkJ Luca SchwarzEric A StandleyElodie DecuypereConstantin G DaniliucDavide AudisioFrédéric TaranFrank Glorius
Published in: Organic letters (2019)
Herein we report on the development of an MS tag screening strategy that accelerates the discovery of photocatalytic reactions. By efficiently combining mechanism- and reaction-based screening dimensions, the respective advantages of each strategy were retained, whereas the drawbacks inherent to each screening approach could be eliminated. Applying this approach led to the discovery of a mild photosensitized decarboxylative hydrazide synthesis from mesoionic sydnones and carboxylic acids as starting materials.
Keyphrases
  • small molecule
  • mass spectrometry
  • high throughput
  • multiple sclerosis
  • ms ms
  • gold nanoparticles