Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central region of Brazil.
Antonio Charlys da CostaAdriana LuchsFlavio Augusto de Pádua MilagresShirley Vasconcelos KomninakisDanielle Elise GillMárcia Cristina Alves Brito Sayão LobatoRafael BrustulinRogério Togisaki das ChagasMaria de Fátima Neves Dos Santos AbrãoCassia Vitória de Deus Alves SoaresXutao DengEster Cerdeira SabinoEric DelwartElcio de Souza LealPublished in: Scientific reports (2018)
In the present article we report the nearly full length genome of a Cosavirus strain (BRTO-83) isolated from a child with acute gastroenteritis, and who is an inhabitant of a rural area in the central region of Brazil. The sample was previously screened and negative for both: common enteric viruses (i.e. rotavirus and norovirus), bacteria, endoparasites and helminthes. Evolutionary analysis and phylogenetic inferences indicated that the Brazilian BRTO-83 Cosavirus strain was a recombinant virus highly related to the E/D recombinant NG385 strain (Genbank JN867757), which was isolated in Nigeria from an acute flaccid paralysis patient. This is the first report of a recombinant E/D Cosavirus strain detected in Brazil, and the second genome described worldwide. Further surveillance and molecular studies are required to fully understand the epidemiology, distribution and evolution of the Cosavirus.