6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice.

Kassem MakkiHarald BrolinNatalia PetersenMarcus HenricssonDan Ploug ChristensenMuhammad Tanweer KhanAnnika WahlströmPer-Olof BerghValentina TremaroliKristina SchoonjansHanns-Ulrich Marschall Fredrik Bäckhed

Published in: Gut (2022)

Modulation of the gut microbiota with oligofructose enriches bacteria involved in 6α-hydroxylated bile acid production and leads to TGR5-GLP1R axis activation to improve body weight and metabolism under western-style diet feeding in mice.

Keyphrases

body weight
high fat diet induced
physical activity
south africa
weight loss
insulin resistance
type diabetes
metabolic syndrome
skeletal muscle