Comparative Epigenetic Profiling Reveals Distinct Features of Mucosal Melanomas Associated with Immune Cell Infiltration and Their Clinical Implications.

Jie Dai Jia Jia Fanshuang Zhang Kaihua Liu Yanfeng Xi Pei Yuan Lili Mao Xue Bai Xiaoting Wei Bingning Wang Jiangtao Li Yang Xu Ting Liu Shuang Chang Yang W Shao Jun Guo Jianming Ying Lu Si

Published in: Cancer research communications (2024)

This study investigated the intricate epigenetic factor of mucosal melanomas contributed to the differential immune checkpoint inhibitor response, and found that PMME exhibited a global hypermethylation pattern and lower gene expression in comparison to NEMM. TERT hypermethylation may contribute to the favorable responses observed in patients with mucosal melanoma undergoing immunotherapy.

Keyphrases

gene expression
dna methylation
ulcerative colitis
atomic force microscopy
single molecule