Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia.
Daniele CaraccioloCaterina RiilloAndrea BalleriniGiuseppe GaipaLudovic LhermitteMarco RossiCirino BottaEugénie DuroyonKatia GrilloneMaria Eugenia Gallo CantafioChiara BuracchiGreta AlampiAlessandro GulinoBeatrice BelmonteFrancesco ConfortiGaetanina GolinoGiada JuliEmanuela AltomareNicoletta PoleràFrancesca SciontiMariamena ArbitrioMichelangelo IannoneMassimo MartinoPierpaolo CorrealeGabriella TalaricoAndrea Ghelli Luserna di RoràAnna FerrariDaniela ConcolinoSimona SestitoLicia PensabeneAntonio GiordanoMarkus HildingerMaria Teresa Di MartinoGiovanni MartinelliClaudio TripodoVahid AsnafiAndrea BiondiPierosandro TagliaferriPierfrancesco TassonePublished in: Journal for immunotherapy of cancer (2022)
Altogether our findings, including the safe UMG1-epitope expression profile, provide a framework for the clinical development of these innovative immune-therapeutics for this still orphan disease.