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Transverse Fluctuations Control the Assembly of Semiflexible Filaments.

Valerio SorichettiMartin Lenz
Published in: Physical review letters (2023)
The kinetics of the assembly of semiflexible filaments through end-to-end annealing is key to the structure of the cytoskeleton, but is not understood. We analyze this problem through scaling theory and simulations, and uncover a regime where filaments' ends find each other through bending fluctuations without the need for the whole filament to diffuse. This results in a very substantial speedup of assembly in physiological regimes, and could help with understanding the dynamics of actin and intermediate filaments in biological processes such as wound healing and cell division.
Keyphrases
  • wound healing
  • single cell
  • cell therapy
  • molecular dynamics
  • low grade
  • mesenchymal stem cells
  • cell migration