Programmed death ligand-1 regulates angiogenesis and metastasis by participating in the c-JUN/VEGFR2 signaling axis in ovarian cancer.
Yufei YangLingfang XiaYong WuHongyu ZhouXin ChenHaoran LiMidie XuZihao QiZiliang WangHuizhen SunXi ChengPublished in: Cancer communications (London, England) (2021)
Our results demonstrated that PD-L1 promoted the angiogenesis and metastasis of ovarian cancer by participating in the c-JUN/VEGFR2 signaling axis, suggesting that the combination of PD-L1 inhibitor and antiangiogenic drugs may be considered as a potential therapeutic approach for ovarian cancer patients.