Mechanical power ratio threshold for ventilator-induced lung injury.

Rosanna D'AlboTommaso PozziRosmery V NicolardiMauro GaliziaGiulia CatozziValentina GhidoniBeatrice DonatiFederica RomittiPeter HerrmannMattia BusanaSimone GattarelloFrancesca CollinoAurelio SonzogniLuigi CamporotaJohn J MariniOnnen MoererKonrad MeissnerLuciano Gattinoni

Published in: Intensive care medicine experimental (2024)

in healthy lungs subjected to 48 h of mechanical ventilation appears to be a threshold for the development of ventilator-induced lung injury, as indicated by the convergence of histological, physiological, and anatomical alterations. In humans and in lungs that are already injured, this threshold is likely to be different.

Keyphrases

mechanical ventilation
acute respiratory distress syndrome
high glucose
intensive care unit
diabetic rats
respiratory failure
drug induced
extracorporeal membrane oxygenation
oxidative stress
endothelial cells