Ruthenium-Catalyzed Meta-Selective C-H Difluoromethylation of Phenol Derivatives.
Xu XuNa TaoWei-Tai FanGuangliang TuJingyao GengJingyu ZhangYing-Sheng ZhaoPublished in: The Journal of organic chemistry (2020)
With pyrimidine as the directing group, we achieved the meta-selective difluoromethylation of phenol derivatives using ruthenium as a catalyst. This synthetic scheme provided an efficient method for the syntheses of fluorine-containing phenol derivatives. A wide variety of phenol derivatives were well-suited, affording the corresponding products in moderate-to-good yields.