Mechanical Thrombectomy Versus Best Medical Treatment in the Late Time Window in Non-DEFUSE-Non-DAWN Patients: A Multicenter Cohort Study.
Tolga Daniel DittrichPeter B SpornsLilian F KriemlerSalome RudinK A T NguyenAnnaelle ZietzAlexandros A PolymerisChristopher TränkaSebastian ThilemannBenjamin WagnerValerian L AltersbergerInes PiotFilip BarinkaSusanne MüllerMartin HänselHenrik GensickeStefan T EngelterPhilippe A LyrerRaoul SutterChristian H NickelMira KatanNils PetersZsolt KulcsarGrzegorz Marek KarwackiMarco PileggiCarlo Walter CeredaSusanne WegenerLeo H BonatiUrs FischerMarios-Nikos PsychogiosGian Marco De MarchisPublished in: Stroke (2023)
Two out of 3 patients with anterior circulation large vessel occlusion presenting in the late time window did not meet the DEFUSE-3 and DAWN inclusion criteria. In these patients, MT was associated with higher odds of favorable functional outcomes without increased rates of symptomatic intracranial hemorrhage. These findings support the enrollment of patients into ongoing randomized trials on MT in the late window with more permissive inclusion criteria.