Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri.
Yue YangQi GongWei WangYing-Le MaoXiao-Rong WangSheng YaoHai Yan ZhangChunping TangYang YePublished in: Journal of natural products (2020)
Three new dimeric diarylheptanoids, taccachanfurans A-C (1-3), a new monomeric diarylheptanoid, taccachannoid A (4), and four known diarylheptanoids (5-8) were isolated from the EtOH extract of the rhizomes of Tacca chantrieri. Their structures were established on the basis of comprehensive spectroscopic data analysis. The absolute configuration of taccachanfuran A (1) was confirmed by single-crystal X-ray diffraction. All the diarylheptanoid dimers contain a ditetrahydrofuran moiety, which has not been described previously for diarylheptanoid compounds. A plausible biosynthetic pathway for the diarylheptanoid dimers is proposed. Compounds 2-4 showed significant neuroprotective activity against Aβ25-35-induced damage in SH-SY5Y cells at the concentrations of 10 and 1 μM. Compounds 3, 4, 6, 7, and 8 showed anti-inflammatory activity in LPS-stimulated murine microglial BV-2 cells at the concentrations of 10 and 1 μM.
Keyphrases
- anti inflammatory
- induced apoptosis
- data analysis
- cell cycle arrest
- oxidative stress
- inflammatory response
- lipopolysaccharide induced
- high resolution
- lps induced
- cell death
- magnetic resonance imaging
- diabetic rats
- signaling pathway
- cell proliferation
- high glucose
- blood brain barrier
- neuropathic pain
- subarachnoid hemorrhage
- mass spectrometry
- molecular dynamics simulations