Innate lymphoid cells regulate radiation-induced skin damage via CCR10 signaling.
Yiwen MaoRui TaoXiaoping CaoQin BaoDong WangYe ZhaoPublished in: International journal of radiation biology (2020)
CCR10-/- mice had lower percentages of ILCs and more skin damage than CCR10+/- mice after irradiation. These findings indicate that skin ILCs are regulated by CCR10, which might be a potential target for reducing the radio-dermatitis.
Keyphrases
- radiation induced
- dendritic cells
- regulatory t cells
- soft tissue
- wound healing
- radiation therapy
- induced apoptosis
- oxidative stress
- high fat diet induced
- cell cycle arrest
- type diabetes
- adipose tissue
- risk assessment
- immune response
- cell death
- signaling pathway
- endoplasmic reticulum stress
- skeletal muscle
- human health
- wild type