The Influence of Light on Reactive Oxygen Species and NF-кB in Disease Progression.
Naresh Kumar RajendranBlassan P GeorgeRahul ChandranIvan Mfouo TyngaNicolette Nadene HoureldAbrahamse HeidiPublished in: Antioxidants (Basel, Switzerland) (2019)
Reactive oxygen species (ROS) are important secondary metabolites that play major roles in signaling pathways, with their levels often used as analytical tools to investigate various cellular scenarios. They potentially damage genetic material and facilitate tumorigenesis by inhibiting certain tumor suppressors. In diabetic conditions, substantial levels of ROS stimulate oxidative stress through specialized precursors and enzymatic activity, while minimum levels are required for proper wound healing. Photobiomodulation (PBM) uses light to stimulate cellular mechanisms and facilitate the removal of oxidative stress. Photodynamic therapy (PDT) generates ROS to induce selective tumor destruction. The regulatory roles of PBM via crosstalk between ROS and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) are substantial for the appropriate management of various conditions.
Keyphrases
- reactive oxygen species
- nuclear factor
- oxidative stress
- photodynamic therapy
- signaling pathway
- wound healing
- toll like receptor
- dna damage
- induced apoptosis
- pi k akt
- ischemia reperfusion injury
- lps induced
- diabetic rats
- ms ms
- fluorescence imaging
- immune response
- cell proliferation
- gene expression
- genome wide
- hydrogen peroxide
- nitric oxide
- heat shock
- binding protein
- heat stress
- endoplasmic reticulum stress